Inhibition of mitochondrial fusion by a-synuclein is rescued by PINK1, Parkin and DJ-1
نویسندگان
چکیده
Frits Kamp*, Nicole Exner, Anne Kathrin Lutz, Nora Wender, Jan Hegermann, Bettina Brunner, Brigitte Nuscher, Tim Bartels, Armin Giese, Klaus Beyer, Stefan Eimer, Konstanze F Winklhofer and Christian Haass* DZNE-German Center for Neurodegenerative Diseases, Munich, Germany, Adolf-Butenandt-Institute, Biochemistry, LudwigMaximilians-University, Munich, Germany, Adolf-Butenandt-Institute, Neurobiochemistry, Ludwig-Maximilians-University, Munich, Germany, European Neuroscience Institute Goettingen and DFG Research Center for Molecular Physiology of the Brain (CMPB), Goettingen, Germany, Center for Neuropathology and Prion Research, Ludwig-MaximiliansUniversity, Munich, Germany and Department of Chemistry, The University of Arizona, Tucson, AZ, USA
منابع مشابه
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
Aggregation of α-synuclein (αS) is involved in the pathogenesis of Parkinson's disease (PD) and a variety of related neurodegenerative disorders. The physiological function of αS is largely unknown. We demonstrate with in vitro vesicle fusion experiments that αS has an inhibitory function on membrane fusion. Upon increased expression in cultured cells and in Caenorhabditis elegans, αS binds to ...
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